CORDIS Project
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The project focuses on developing a novel method to study DNA-protein interactions using large, freely suspended DNA molecules in nanofluidic channels. This approach aims to enhance our understanding of DNA repair mechanisms, particularly in the context of serious genetic damage and diseases like cancer.
DNA-protein interactions are at the core of the function of every human cell.
Single DNA molecule methods have revolutionized our understanding of such interactions. A vast majority of these methods are based on attaching the DNA, at one or both ends, to a bead or a surface.
This gives ultimate control of the positioning of the DNA molecules and forces that can be applied to them but makes it difficult to investigate interactions with DNA ends, especially when more than one single DNA molecule i…
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