CORDIS Project
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This project investigates the use of nanoparticles coated with specific peptide-MHC complexes to modulate immune responses in type 1 diabetes. By promoting the formation of regulatory T-cells and B-cells, it aims to restore normal blood sugar levels while maintaining overall immune function.
The complexity of autoimmune responses is a barrier to the design of strategies that can selectively purge the immune system of autoreactivity without impairing systemic immunity.
Recently, Santamaria et al. have shown that nanoparticles (NPs) coated with type 1 diabetes (T1D)-relevant peptide–MHC (pMHC) complexes can restore normoglycemia in diabetic animals by blunting the diabetogenic autoimmune response without impairing systemic immunity. pMHC class II-NP therapy functions by expanding, in…
FUNDACIO DE RECERCA CLINIC BARCELONA-INSTITUT D INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
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