CORDIS Project
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This project develops nanoparticle vaccines targeting bacterial infections by leveraging advanced protein design and antibody analysis. It aims to create vaccines that provide broad protection against multiple pathogens while avoiding antimicrobial resistance.
Vaccines are the most effective single measure to protect populations against infectious diseases without promoting antimicrobial resistance (AMR).
In this proposal, I intend to harness the rapid developments in protein design and quantitative and structural mass spectrometry to i) enable detailed molecular characterization of circulating serum antibody repertories, ii) establish a generalizable framework for antibody-guided design of next-generation nanoparticle vaccines against bacteria and ii…
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