CORDIS Project
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This project proposes a novel approach to structure determination using magnetic resonance force microscopy, which combines magnetic resonance imaging with scanning force microscopy. It aims to achieve nanometer resolution for analyzing complex proteins.
There are three major problems in structure determination that can be circumvented using the proposed method.
First, currently available methods such as nuclear magnetic resonance, X-ray crystallography and cryo electron microscopy require averaging over thousands of identical molecules at least.
Second, X-ray crystallography and cryo electron microscopy lead to radiation damage of the sample.
Third, NMR and X-ray crystallography are limited to a certain molecular size or shape.
Magnetic Resonan…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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