CORDIS Project
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This research investigates the molecular organization of axo-axonic synapses in the brain, focusing on the axon initial segment of pyramidal neurons. It aims to understand how this organization affects neuronal output and its changes during activity and in schizophrenia models using advanced microscopy and electrophysi…
Neurons in the brain have extensive dendritic arbours that receive thousands of synaptic inputs all along it.
The transformation of all these inputs to an output in a single neuron occurs through the integration of synaptic events and the generation of an action potential (AP) at the axon initial segment (AIS).
The AIS, therefore, is the site that controls neuronal output by gating the generation of APs.
It has been recently shown that this neuronal compartment can be reorganized following a cha…
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