CORDIS Project
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This project focuses on designing proteins that can mimic and modulate interactions between proteins and nucleic acids, which are crucial for various cellular processes. By utilizing advanced computational methods and structural data, the aim is to create novel protein-based therapeutics for applications in synthetic b…
Protein–nucleic acid (NA) interactions are fundamental to many cellular processes, and their disruption can lead to diseases such as autoimmune disorders and cancer.
However, targeting NA-binding proteins with small molecules is difficult due to the “undruggable” nature of their interfaces.
Recent advancements in computational protein design and deep learning have created new opportunities for the development of protein-based therapeutics.
However, current methods struggle to design proteins tha…
UNIVERSITAT ZURICH
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