CORDIS Project
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This project investigates the NLRP3 inflammasome, a complex involved in immune responses to pathogens and tissue damage. It aims to understand how NLRP3 is activated and regulated, and to develop specific inhibitors that could lead to new anti-inflammatory treatments.
Inflammasomes are cytosolic multi-protein complexes that form in response to a wide range of pathogens, tissue damage, and other harmful stimuli.
Members of the family of NOD-like receptors (NLRs) sense these pathogen and danger associated molecular patterns, triggering innate immune responses. NLRP3 is a well-studied NLR whose activation by a broad spectrum of stimuli leads to inflammasome formation and pyroptosis.
Yet, the mechanisms inducing NLRP3 activation and the way how antagonistic small…
UNIVERSITATSKLINIKUM BONN
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