CORDIS Project
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This project focuses on developing new antiviral drugs to combat influenza, particularly the H5N1 strain. It aims to synthesize fluorinated sialic acid analogues that inhibit influenza neuraminidases, potentially reducing the risk of drug resistance.
The recent emergence of the highly pathogenic H5N1 strain of avian influenza now circulating in Asia, EU and Africa has increased concerns that a new, and devastating, influenza pandemic may be imminent.
Antiviral drugs represent the first line of defence for pandemic outbreaks, and governments are currently stockpiling the influenza neuraminidase inhibitors Relenza® (Zanamivir) and Tamiflu® (Oseltamivir) in preparedness.
These neuraminidase inhibitors are highly potent and specific inhibitors a…
UNIVERSITY OF BATH
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