CORDIS Project
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This project focuses on developing RNAylated proteins, which are proteins covalently linked to RNA, to enhance RNA therapy. It aims to create a novel tool for regulating cellular processes and improving RNA delivery for therapeutic applications.
Background:
We discovered that NAD-capped RNAs can be covalently attached to specific target proteins by the phage T4 ADP-ribosyltransferase (ART) ModB, which we term RNAylation.Scientific problem:
RNA therapy has almost limitless yet unexplored potential.
Its translation into the clinics, however, requires optimal RNA delivery with high RNA stability, efficient cellular internalisation and precise target affinity.
Hypothesis:
Protein-RNA interactions are ubiquitous and central in biological con…
PHILIPPS UNIVERSITAET MARBURG
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