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NACHO investigates the impact of nicotine on insulin secretion and beta cell function, particularly in the context of type 2 diabetes. The project uses advanced genetic models to understand how nicotine affects cellular responses and may lead to personalized treatment approaches.
Tobacco abuse elevates the risk of developing type 2 diabetes (T2D).
This effect is attributed to nicotine, the major addictive compound in cigarettes and chewing tobacco.
Nicotine acutely activates nicotinic receptors (nAchRs) while extended exposure results in receptor desensitization.
Accumulating evidence suggests that long-term exposure to nicotine impairs beta cell function.
Recent results (host laboratory) demonstrate that nicotine acutely modulates insulin secretion and that reduced nAch…
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