CORDIS Project
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The Nab-Heart project aims to develop a selective inhibitor for a specific kinase enzyme involved in cardiac function. By using Nanobodies linked to a new peptide, the project seeks to prevent life-threatening arrhythmias in various cardiac conditions, enhancing treatment options for patients.
In cardiac cells, kinase enzymes are key modulators of calcium homeostasis, mitochondrial function, excitation-contraction coupling, and metabolism.
Of these, the delta isoform of Ca 2+ /Calmodulin-dependent kinase (Camk2d) is particularly relevant to the induction of life-threatening cardiac arrhythmias.Of the several promising small molecule and peptide Camk2d inhibitors proposed in pre-clinical investigations, none has entered clinical applications.
The severity of side effects, a well-known…
UNIVERSITA DEGLI STUDI DI PAVIA
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Italy, Pavia
Type: Company (for-profit)
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: No
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