CORDIS Project
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The MYO_MATRIX project investigates the role of the extracellular matrix in muscular dystrophies, focusing on how it affects muscle regeneration and fibrosis. By analyzing various muscle conditions, the project aims to identify molecular components that could serve as therapeutic targets for treating these debilitating…
Healthy skeletal muscle has a powerful capacity to regenerate after an injury.
On the opposite, muscular dystrophies (MDs) are devastating diseases where these regenerative capacities are overwhelmed and the muscle fibers are progressively replaced by fibrosis, leading to muscle loss and finally to death.
Fibrosis is the final outcome of excessive production of molecules constituting the extracellular matrix (ECM).
However, ECM alterations in MDs have been considered only as the result of muscle…
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