CORDIS Project
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This project focuses on developing Mycolic Acid Cyclopropane Synthases as biocatalysts for the sustainable synthesis of cyclopropane-containing compounds. By utilizing these enzymes, the project aims to create safer and more environmentally friendly methods for producing valuable chemical structures.
Cyclopropane rings are a key structural motif that may be found in a wide range of natural products, chemicals, fragrances and pharmaceuticals.
Current methods for the manufacturing of cyclopropane-containing molecules show significant limitations in terms of safety, environmental impact and green metrics.
Only a few biocatalytic methodologies for the asymmetric synthesis of cyclopropanes have been developed so far, and they rely on repurposed or artificial heme enzymes (P450, myoglobin).
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