CORDIS Project
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This project investigates the role of mycothiol, a redox buffer in certain bacteria, in response to oxidative stress. It focuses on understanding how mycothiol modifications affect protein function and bacterial virulence, using advanced mass spectrometry and genetically encoded biosensors for real-time monitoring duri…
Glutathione serves as the major thiol-redox buffer in the defense against Reactive Oxygen Species (ROS) in eukaryotes.
Firmicutes bacteria utilize as thiol redox buffer bacillithiol (Cys-GlcN-Mal, BSH) and Actinomycetes produce the related redox buffer mycothiol (AcCys-GlcN-Ins, MSH).
In eukaryotes, proteins are post-translational modified to S-glutathionylated proteins in response to oxidative stress. S-glutathionylation has emerged as major redox-regulatory mechanism and protects cysteine resi…
FREIE UNIVERSITAET BERLIN
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Germany, Greifswald
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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