CORDIS Project
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This project explores how the tuberculosis bacterium Mycobacterium tuberculosis acquires iron through specialized molecules called siderophores. It aims to understand the transport mechanisms of these molecules and develop new strategies to combat tuberculosis by targeting iron acquisition.
To infect humans, the devastating pathogen Mycobacterium tuberculosis critically depends on two closely related siderophores – soluble carboxymycobactin and membrane-bound mycobactin – which capture iron with high affinity inside the host cell.
Despite their undisputed importance for virulence, little is known about how these siderophores are exported and imported across the two mycobacterial membranes.Building on my lab’s experience in elucidating transport processes of pathogenic bacteria, we…
UNIVERSITAT ZURICH
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