CORDIS Project
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This research focuses on developing tumor-specific inhibitors for DNA topoisomerases, crucial enzymes in cancer therapy. By understanding how these enzymes are regulated during DNA processes, the project aims to create targeted treatments that minimize damage to healthy cells while effectively combating cancer.
Inhibitors of DNA topoisomerases (TOPs, TOP1, TOP2) are mainstays of anticancer therapy.
While they have proven effective, the toxicity of current TOP drugs, caused by DNA damage-induced apoptosis of non-cancer cells, limits their use in clinic.
Development of tumour-specific TOP inhibitors will require a better knowledge of the mechanisms of TOPs.
This research program aims to define how TOP are regulated during transcription and replication and develop drugs that target these regulatory mechan…
KAROLINSKA INSTITUTET
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