CORDIS Project
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This project focuses on understanding protein misfolding diseases by studying muscle protein disorders in the nematode Caenorhabditis elegans. It aims to develop new tools to monitor protein aggregation and investigate the cellular mechanisms that can rescue these defects, shedding light on fundamental protein quality…
Mutations in certain proteins can cause their misfolding and aggregation, posing a potential threat to the health of an organism.
Protein aggregation is counteracted by protein quality control (PQC) mechanisms that reduce the amounts of damaged molecules.
As we age, however, the crucial surveillance mechanisms weaken and become less effective, leading to protein misfolding diseases.
The most well-known protein disorders, or proteinopathies – Alzheimer's, Huntington's, and Parkinson's diseases –…
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