CORDIS Project
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This project investigates the mechanisms of neurovascular coupling in the brain, focusing on how blood flow responds to neuronal activity. It aims to provide insights into the cellular interactions that support brain function and their implications for neurodegenerative diseases.
Neuronal computations in the brain require a high metabolic budget yet the brain has extremely limited resources; calling for an on-demand, robust supply system to deliver nutrients to active regions.
In most cases, neuronal activity results in an increase in blood flow to the active area, a phenomenon called functional hyperaemia.
This coupling between neuronal and vascular activtuy underpins the mechanism enabling fMRI to map neuronal activity based on vascular dynamics; further, malfunction o…
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