CORDIS Project
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Project MultiProp focuses on enhancing synthetic organic chemistry by utilizing small-ring propellanes in multicomponent reactions to create bicyclo[n.1.1]alkanes. These unique hydrocarbons are promising for drug design due to their improved pharmacological properties and structural rigidity, addressing the need for ef…
Project MultiProp aims to advance the field of synthetic organic chemistry by exploring the use of small-ring propellanes in multicomponent reactions (MCRs).
Radical ring-opening reactions of these propellanes lead to bicyclo[n.1.1]alkanes (BCAs), which are sp3 rich "cage" hydrocarbons that are of high interest in drug design.
Specific examples include bicyclo[1.1.1]pentanes (BCPs), which have demonstrated to be bioisosteres of para-substituted benzene rings, alkynes, and tert-butyl groups; and…
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