CORDIS Project
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This project aims to create novel organelles in eukaryotic cells that can perform the entire central dogma of molecular biology. These organelles will enable advanced protein engineering and the development of new living systems with expanded genetic codes for various biotechnological applications.
The emergence of organelles dedicated to specific cellular functions drove the evolution of more complex eukaryotic organisms.
We recently created membraneless organelles inside eukaryotic cells dedicated to orthogonal translation, which opened a new path to residue-specific protein engineering using genetic code expansion.
We now want to design novel organelles into eukaryotes that will internally enact the entire central dogma of molecular biology.
This will supplement the complex eukaryotic c…
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