CORDIS Project
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This project explores the evolution of specificity in bacterial communication systems, focusing on the Rap-Phr system. By combining modeling and experimental techniques, it seeks to understand how these systems diversify and influence cellular interactions and selection processes.
The evolution of specificity between interacting biological molecules underlies the diversification and expansion of biological pathways. A shift in specificity poses a serious theoretical problem; it requires coordinated mutations in the interacting partners, but mutation in one partner may lead to loss of interaction and functional failure.
While some theoretical suggestions were proposed to solve this 'specificity valley crossing' problem, it remains a challenge to study this problem empirica…
TEL AVIV UNIVERSITY
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