CORDIS Project
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This project investigates how hematopoietic stem cells respond to stress and injury. By utilizing zebrafish genetics, the research aims to reveal the signaling pathways that control stem cell activation and regeneration, with potential therapeutic implications for blood disorders.
Hematopoieic stem cells (HSCs) are characterized by their ability to self-renew and differentiate into cells of all hematopoietic lineages.
During steady-state, HSCs are mostly quiescent and responsible for normal hematopoietic differentiation.
In cases of stress such as infection or injury, HSCs need to be activated and repair the hematopoeitic system in a regenerative response that involves synchronous and hierarchical replacement of the hematopoietic lineages.
Multiple signaling pathways cons…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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