CORDIS Project
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This project investigates the aging of hematopoietic stem and progenitor cells in the bone marrow. It aims to visualize and analyze how the microenvironment and niche components change with age, affecting blood cell production and overall hematopoietic health.
Sustained production of mature blood cell types relies on the continuous differentiation and self-renewal of a rare subset of hematopoietic stem and progenitor cells (HSPCs).
HSPCs reside in bone marrow (BM) cavities within defined anatomical locations, also known as niches, where they receive and integrate regulatory cues that control their functional capacities to suit the changing physiological demands.
BM spaces are extremely complex environments containing hematopoietic cells at different s…
University of Zurich
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