CORDIS Project
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This project investigates the functional roles of long non-coding RNAs (lncRNAs) in various species by developing a new computational framework that accounts for multiple structural forms. The research aims to enhance understanding of lncRNA evolution and their implications in human diseases.
Long non-coding RNAs (lncRNAs) are abundant in mammalian transcriptomes.
However, it remains unclear how many of them are functional, and how their functions are performed.
LncRNAs seem to be poorly conserved at the sequence level, but some of them share conserved structural elements and are present at syntenic genomic positions in different species. A recent study revealed that secondary structure constrains sequence variation in lncRNAs, so that polymorphisms are depleted in low accessibility…
BARCELONA SUPERCOMPUTING CENTER CENTRO NACIONAL DE SUPERCOMPUTACION
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