CORDIS Project
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This project develops a microarray platform for the simultaneous detection of two important DNA modifications, 5-methylcytosine and 5-hydroxymethylcytosine, in blood samples. This technology aims to improve the diagnosis and monitoring of blood cancers through a more efficient and precise method.
Blood cancers remain challenging to diagnose and monitor due to the standard of care requirement for bone marrow biopsies and limitations in current biomarker detection technologies. DNA modifications, specifically 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)—are powerful epigenetic regulators in blood cancer development, providing valuable diagnostic and prognostic information.
Despite their clinical importance, current technologies fail to simultaneously detect both 5mC and 5hmC w…
TEL AVIV UNIVERSITY
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