CORDIS Project
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This project investigates how neurons reorganize their microtubules after axon removal, focusing on the mechanisms that govern this process. It aims to understand the role of specific proteins in neuronal regeneration.
Neurons are highly polarized cells, possessing two distinct types of processes, dendrites and a single axon.
In cultured mammalian neurons, axons have uniform polarity microtubules (MTs) with plus ends distal to the cell body, while dendrites have mixed polarity with about half plus-end-out and half minus-end-out MTs.
Several studies suggest that neurons have a tremendous capacity for axon regeneration, even in response to total axon removal they can convert a dendrite to a regenerating axon.
Th…
UNIVERSITEIT UTRECHT
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