CORDIS Project
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This project aims to understand the role of mTOR signaling in liver cancer development. By utilizing CRISPR technology in mouse models, it seeks to uncover the interactions between tumor suppressor networks and mTOR dysregulation, potentially leading to new treatment strategies.
Hepatocellular carcinoma (HCC) is the predominant form of liver cancer and a leading cause of cancer death worldwide.
Inactivation of different tumor suppressors, whose cooperation forms tumor suppressor networks, has been linked to HCC development, but the genetic events involved in HCC are still poorly understood.
Mammalian target of rapamycin (mTOR) signaling is essential for cell growth and metabolism, and its hyper-activation plays an important role in pathogenesis and prognosis of HCC.
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