CORDIS Project
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This project investigates the genetic and epigenetic factors influencing mesial temporal lobe epilepsy with hippocampal sclerosis. By analyzing gene expression and methylation in patient samples, the research aims to uncover mechanisms that contribute to the disease and identify potential therapeutic targets.
Epilepsy is the second most common neurological disorder after stroke and mesial temporal lobe epilepsy with hippocampal sclerosis (mTLE+HS) represents the most common epilepsy syndrome in adult patient with medically intractable partial epilepsy.
Studies of genome-wide association (GWA) with epilepsy are critical to provide an unbiased assessment of genes contributing to disease risk and/or response to treatment.
However the results of GWA studies give little information about the underlying di…
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