CORDIS Project
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This project aims to identify Mycobacterium tuberculosis-derived epitopes presented by HLA-E, focusing on their role in activating CD8+ T-cells. The research seeks to enhance understanding of immune responses to tuberculosis and inform vaccine development.
Based on recent work from the Tuberculosis Research group in the Department of Infectious Diseases at LUMC on the discovery of highly in vivo expressed Mycobacterium tuberculosis (Mtb) antigens, using genome wide bioinformatics and immunomics approaches, I here propose to identify Mtb derived epitopes presented by HLA-E from the most immunogenic and protective antigens identified thus far during Mtb infection.
HLA-E restricted Mtb specific CD8+ T-cells represent a novel human T-cell subset, whic…
Leiden University Medical Center
ACADEMISCH ZIEKENHUIS LEIDEN
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