CORDIS Project
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This project focuses on developing a technology to map the effects of mitochondria-derived reactive metabolites on immune responses in specific cell types over time. By controlling the dosage and timing of these metabolites, the research aims to uncover how they influence signaling pathways in various disease contexts…
Mitochondria-derived reactive metabolites (mt-REMs) drive context-specific immunomodulatory behaviors during metabolic reprogramming.
Yet, no method can interrogate the cause-and-effects of individual mt-REMs with locale specificity and temporal resolution.
Mapping mt-REM-directed signaling changes with spatiotemporal resolution would thus be transformational. I will develop a spatiotemporally-resolved in-vivo mt-REM-responsivity-mapping technology.
This cross-disciplinary innovation will enabl…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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