CORDIS Project
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This project develops a novel method for synthesizing guide RNA in the CRISPR/Cas9 genome editing system, aiming to enhance specificity and reduce off-target effects. It explores innovative imaging techniques and light-induced DNA damage methods to improve the functionality and application of CRISPR technology in thera…
CRISPR/Cas9 has been extensively studied for genome editing, but its therapeutic application has been hampered by off-target effects.
Site-specific modification of single guide (sg) RNA in CRISPR system is a potential means to expand the utility of CRISPR-Cas genome editing.
To address this, and reduce of synthetic burden of sgRNA we propose a ‘click’ ligation method to synthesize sgRNA where two chemically modified oligonucleotides are joined together using CuAAC chemistry.
The resultant artifi…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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