CORDIS Project
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This project investigates the origins of tumor heterogeneity in breast cancer by studying the impact of specific mutations on mammary stem cells. It aims to develop a new mouse model to better understand cancer progression and resistance to therapies.
One of the most challenging questions in breast cancer biology is to elucidate the origin of tumor heterogeneity and its contribution to therapy failure.
Accumulating evidence suggests that the cell-of-origin, the cell that acquires the first oncogenic event, may define the molecular portrait of the resulting tumor.
The fate of mammary Stem Cells (MSC) upon oncogenic perturbation has been poorly explored.
Moreover, the Phosphoinositide 3-kinase (PI3K) pathway regulates proliferation/differentiat…
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