CORDIS Project
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This project investigates the role of Myocardin-related transcription factors in cancer cell behavior, particularly their influence on cell senescence and invasion. By exploring these mechanisms, the research aims to identify potential therapeutic strategies for cancer treatment.
Myocardin-related transcription factors (MRTFs) are G-actin binding proteins which act as transcriptional co-activators Myocardin-related transcription factors (MRTFs) are G-actin binding proteins which act as transcriptional co-activators in association with the transcription factor SRF. MRTF-SRF target genes encode numerous proteins involved in actin dynamics, cell adhesion, migration and contractility.
The subcellular localization of the MRTFs is controlled by actin binding which inhibits the…
THE FRANCIS CRICK INSTITUTE LIMITED
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