CORDIS Project
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This project investigates the formation and structure of messenger ribonucleoprotein particles (mRNPs), essential for gene expression regulation. By utilizing advanced purification and imaging techniques in yeast, it aims to clarify the mechanisms of mRNP packaging and its dynamic architecture, contributing to our unde…
An important step of gene expression is the formation of a messenger ribonucleoprotein particle (mRNP).
The messenger RNA (mRNA) is synthesized by RNA polymerase II transcribing a protein-coding gene.
The mRNA is processed, i.e. capped, spliced and polyadenylated, and packaged into an mRNP by binding of RNA-binding proteins (RBPs).
The RBPs bound to the mRNA are essential for the stability of the mRNP, control nuclear mRNA export and often determine cytoplasmic processes such as mRNA localizatio…
JUSTUS-LIEBIG-UNIVERSITAET GIESSEN
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