CORDIS Project
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This project explores how cells respond to stress by reprogramming mRNA translation. Using advanced imaging techniques, it aims to uncover the mechanisms behind selective translation of stress-related messages to maintain cellular health.
Cells are frequently exposed to stress conditions, which can disrupt cellular homeostasis and result in cell death.
To minimize the damage and adapt to the stress condition, eukaryotic cells employ a highly conserved signaling pathway, the integrated stress response, which integrates a variety of intrinsic and extrinsic stress signals to reprogram mRNA translation.
Consequently, translation of most mRNAs is inhibited to conserve energy, while a select group of stress-related mRNAs is preferentia…
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
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