CORDIS Project
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This project investigates how dendritic cells can promote tolerance to harmless antigens in asthma by using lipid nanoparticles. It aims to understand immune responses to mRNA vaccines in the lung environment and explore potential protective strategies against asthma triggered by allergens.
Dendritic cells (DCs) are antigen presenting cells that promote immunity to pathogens, as well as tolerance to innocuous antigens, and are therefore critical regulators of both immunity and immune homeostasis.
However, during asthma this ability to promote peripheral tolerance is dysregulated, leading to the formation of inappropriate TH2 responses to harmless antigens, and allergic inflammation in the airway.
Peripheral tolerance has been postulated to be promoted by DCs undergoing homeostatic…
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