CORDIS Project
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This project investigates the export of messenger RNA (mRNA) from the nucleus to the cytoplasm, focusing on how mature mRNA is selectively packaged to prevent degradation. It employs advanced techniques to identify proteins that facilitate this process, aiming to enhance understanding of gene expression mechanisms.
The export of mRNA from the nucleus to the cytoplasm is an essential step in eukaryotic gene expression.
This process requires that only fully processed mRNAs are exported, while undesirable RNAs are degraded in the nucleus.
This selectivity is proposed to be mediated by the packaging of mature mRNA by export factors, protecting mRNA from nuclear degradation and licensing it for export to the cytoplasm.
However, this model has not been directly and thoroughly tested.
Furthermore, the full range…
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