CORDIS Project
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This project investigates the dynamic motions of the sodium voltage-gated ion channel Nav1.5, which is critical for cardiac action potential. It aims to understand how mutations and drugs affect these dynamics, potentially informing new treatments for heart arrhythmias.
The sodium voltage-gated ion channel Nav1.5 is a key player in shaping the cardiac action potential.
Hundreds of pathological mutations that lead to the dysfunction of Nav1.5 are linked to severe pathologies, such as life-threatening arrythmias.
The function of these channels is based on precise voltage-dependent molecular motions that result in the opening and closing of their sodium-conducting pore.
Despite very recent advances in determining their atomic structure, knowledge of the dynamics o…
KOBENHAVNS UNIVERSITET
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