CORDIS Project
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The MOVEMeNt project focuses on understanding the molecular mechanisms that make certain motor neurons vulnerable in diseases like amyotrophic lateral sclerosis. By analyzing specific neuron subtypes, the project aims to identify potential therapeutic targets for these degenerative conditions.
Alpha motor neurons (aMN) are a clinically relevant neuronal population that selectively degenerates in neuromuscular diseases, including amyotrophic lateral sclerosis (ALS) and spinal bulbar muscular atrophy (SBMA).
Distinct classes of aMNs (SFR, FFR and FF) degenerate at different rate in these diseases, with the fast fatigable (FF) MNs degenerating first.
The molecular mechanisms underlying this selective vulnerability are only partially known.
Understanding the molecular logics that shape th…
UNIVERSITA DEGLI STUDI DI PADOVA
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