CORDIS Project
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This project investigates how new oligodendrocytes and myelin are formed in the adult central nervous system, focusing on the role of electrical activity in stimulating oligodendrocyte precursor cells. It aims to understand how these processes influence motor skill learning and neural plasticity.
Recently it has become clear that new oligodendrocytes and myelin are generated throughout adult life in rodents.
Some major axon tracts including the corpus callosum contain a majority of unmyelinated axons even in maturity, suggesting that at least some of the adult-born oligodendrocytes might myelinate previously naked axons.
This would be expected to alter dramatically the conduction properties of the newly-myelinated axons and the properties of the circuits in which they participate, cont…
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