CORDIS Project
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This project investigates how motor proteins influence the correction of errors in chromosome attachment during cell division. By studying the roles of specific proteins and tension dynamics, the research aims to clarify mechanisms that prevent chromosome missegregation, which is linked to cancer development.
Accurate chromosome distribution during mitosis requires that each pair of sister chromatids attaches to microtubules from opposite spindle poles via centromere-based kinetochores.
However, incorrect kinetochore-microtubule attachments can be formed.
These errors must be corrected to prevent chromosome missegregation and the resulting aneuploidy, an abnormal chromosome count characteristic of most human cancers.
Error correction relies on the centromere/kinetochore-localised kinase Aurora B, whi…
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