CORDIS Project
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This project investigates how the metabolism of T cells affects their movement within tumors, aiming to enhance their ability to infiltrate solid cancers. By understanding and manipulating these metabolic factors, the project seeks to improve the effectiveness of immunotherapy treatments, particularly for patients with…
Background.The tumor microenvironment markedly limits intra-tumoral T cell motility and the contact with tumor cells.
Such a defective intra-tumoral motility of T cells is one of the main reasons explaining why current treatments based on reinvigoration/infusion of T cells to fight human solid cancers are unsuccessful.
Metabolic reactions support T cell migration.
Although T cell metabolism is severely de-regulated within different tumor areas, how this specifically affects intra-tumoral T cell…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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