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The MOSAIC project aims to explore the evolutionary dynamics of the dengue virus non-structural protein 1 (NS1) by assessing its variants' effects on viral infection in mosquito and human cells. This research will enhance understanding of host-specific interactions and contribute to the development of new strategies fo…
Dengue virus (DENV) is the most prevalent arbovirus worldwide and its ability to rapidly evolve and adapt complicates efforts to control its spread. A key factor in the replication cycle of DENV is the multifunctional non-structural protein 1 (NS1), which is involved in viral replication, transmission, and pathogenesis.
Despite its importance, the evolutionary constraints and host-specific functions of NS1 remain poorly understood.To address this gap, I propose
MOSAIC: a comprehensive approach t…
INSTITUT PASTEUR
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