CORDIS Project
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This project explores the regulatory mechanisms of intestinal stem cells, focusing on the Wnt signaling pathway and its negative feedback loops. It aims to understand how these signals are altered in diseases like cancer and inflammation.
Stem cells at the base of the intestinal crypts are in a dynamic equilibrium with their differentiated derivatives.
Homeostatic equilibria depend on the presence of negative feedback loops.
The role of the Wnt signaling pathway as a driver of epithelial stem cell self renewal and proliferation in the intestine has been relatively well characterized.
Much less is known about the negative feedback signals that must exist to control stem cell behavior and the way these may be deregulated in disease…
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
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Leiden University Medical Center
Netherlands, Leiden
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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