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The MorphoLADs project investigates the three-dimensional organization of the genome, focusing on Lamina-Associated Domains. It aims to create an atlas of these domains in different cell types to understand their role in gene regulation and cellular function.
The three-dimensional organization of the genome is emerging as a critical regulator of nuclear functions.
But we are only beginning to define the diverse nuclear morphologies of different cell types and understand their cell-specific functions.
To address this issue, I will focus on Lamina-Associated Domains (LAD), which are large heterochromatic domains anchored to the nuclear lamina. LADs help partition silent heterochromatin from active euchromatin enabling the tridimensional organization of…
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