CORDIS Project
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This research explores how the Drosophila morphogen Decapentaplegic regulates cell growth and division during development. By studying the relationship between morphogen gradients and cell cycle dynamics, the project aims to uncover mechanisms that could inform our understanding of tumor formation.
As well as controlling patterning, morphogens such as the Drosophila BMP homolog Decapentaplegic (Dpp) also regulate growth during development, but how they do so remains largely unclear.
One privileged hypothesis, called the steepness hypothesis, suggests that cells in a tissue read spatial differences in the morphogen gradient and divide accordingly.
However, the host lab recently discovered a novel mechanism by which the Dpp gradient controls growth: in the Drosophila wing disc, cells are abl…
UNIVERSITE DE GENEVE
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