CORDIS Project
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This project investigates how cell shape changes during development influence communication between cells and their genetic programming. It focuses on the Notch signaling pathway, using advanced imaging and modeling techniques to understand the interplay of signaling, genetics, and morphology in cell differentiation.
During development, cells differentiate into well defined patterns through an orchestrated program in space and time.
This differentiation into different cell states is coordinated by intercellular signaling and is interpreted via intracellular genetic circuits.
However, many developmental processes also involve changes in cell morphology that occur concurrently with the differentiation process.
How such morphological changes affect intercellular signaling?
How cell morphology changes are contro…
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