CORDIS Project
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MONO-FUN-CV investigates the role of specific proteins and microRNAs in atherosclerosis, a major cause of cardiovascular diseases. The project aims to uncover new therapeutic targets by exploring the interactions between these molecules and their implications for disease mechanisms.
Atherosclerosis is the major underlying pathology of cardiovascular diseases (CVD), which remain the leading cause of death worldwide.
The relevance of miRNAs in vascular biology, atherosclerosis and CVD has been well established.
Our discovery of an aptamer-like binding of an endogenous miRNA to proteins, namely that of nuclear miR-126-5p to caspase-3, as facilitated by the RNA-binding protein MEX3A has extended the classical paradigm of miRNA function in the RISC, adding a new layer to the mec…
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
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Germany, Munchen
Type: Public body
Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
SME: No
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