CORDIS Project
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The MONOCLE project focuses on understanding the role of non-classical monocytes in atherosclerosis, a major cause of cardiovascular disease. By utilizing a novel mouse model, the research aims to uncover new therapeutic targets for combating this health issue.
Cardiovascular disease (CVD) is the main cause of death worldwide, and accounts for 40% of deaths within the EU.
Monocytes are immune cells that are directly implicated in atherosclerosis, the leading cause of CVD.
In both mouse and human there are two principle monocyte subsets, termed 'classical' and 'non-classical'.
The classical monocyte subset is a key driver of atherosclerosis, whereas evidence suggests that the non-classical monocyte subset plays a protective role in disease.
However, dir…
THE UNIVERSITY OF EDINBURGH
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