CORDIS Project
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This project aims to enhance our understanding of chromosome organization during cell division by developing advanced imaging techniques. It focuses on real-time, three-dimensional visualization of metaphase chromosomes to study their structure, protein dynamics, and mechanics, which is crucial for understanding geneti…
Chromosomes assume their most compact state during metaphase just before they are separated.
In this process of celldivision the chromosomes experience high forces and genomic defects can occur then.
Many techniques have builtconsiderable understanding of metaphase chromosome structure and a multitude of models have been put forward howcells organize their chromosomes during metaphase.
Yet, given the complexity of the process and limitations of the methodsto study them, it is far from being full…
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